The Multifunctional Ca /Calmodulin-dependent Kinase II (CaMKII ) Controls Neointima Formation after Carotid Ligation and Vascular Smooth Muscle Cell Proliferation through Cell Cycle Regulation by p21*
نویسندگان
چکیده
Weiwei Li, Hui Li, Philip N. Sanders, Peter J. Mohler, Johannes Backs, Eric N. Olson, Mark E. Anderson, and Isabella M. Grumbach 1 From the Division of Cardiovascular Medicine/Department of Medicine, Carver College of Medicine, University of Iowa, Iowa City, Iowa, the Iowa City VA Medical Center, Iowa City, Iowa 52242, the Department of Internal Medicine III, University of Heidelberg, 69120 Heidelberg, Germany, and the Department of Molecular Biology, University of Texas Southwestern Medical Center, Dallas, Texas 75390
منابع مشابه
The multifunctional Ca2+/calmodulin-dependent kinase II regulates vascular smooth muscle migration through matrix metalloproteinase 9.
The multifunctional CaMKII has been implicated in vascular smooth muscle cell (VSMC) migration, but little is known regarding its downstream targets that mediate migration. Here, we examined whether CaMKII regulates migration through modulation of matrix metalloproteinase 9 (MMP9). Using CaMKIIδ(-/-) mice as a model system, we evaluated migration and MMP9 regulation in vitro and in vivo. After ...
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House SJ, Ginnan RG, Armstrong SE, Singer HA. Calcium/ calmodulin-dependent protein kinase IIisoform regulation of vascular smooth muscle cell proliferation. Am J Physiol Cell Physiol 292: C2276–C2287, 2007. First published January 31, 2007; doi:10.1152/ajpcell.00606.2006.—There is accumulating evidence that Ca -dependent signaling pathways regulate proliferation and migration of vascular smoot...
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